Li Y, Wang XY, Shen SR
[Efficacy of 4 kinds of triple strategy for Helicobacter pylori eradication.] [English Abstract, Journal Article]
Zhong Nan Da Xue Xue Bao Yi Xue Ban 2008 Dec; 33(12):1129-31.
Objective To evaluate the efficacy and safety of 4 kinds of triple strategy of Helicobacter pylori(Hp) eradication.Methods A total of 307 patients who suffered from Hp infection, confirmed by rapid urease test(RUT) and 14C-urea breath test(UBT),were randomly divided into 4 groups. Each group had 80, 76, 77, and 74 patients respectively. Group A was treated with rabeprazole, clarithromycin, and furazolidone (RCF)ûGroup B with ranitidine bismuth citrate, clarithromycin, and furazolidone (BCF)ûGroup C with rabeprazole, amoxicillin, and furazolidone(RAF)ûwhile Group D with ranitidine bismuth citrate, amoxicillin, and furazolidone (BAF). Hp was detected by RUT and UBT at 4 weeks after later treatment. Results Hp eradication rates of group A,B,C, and D were 90.0%,67.1%,62.3%,and 45.9%,respectively. The difference between Group A and Group B, Group A and Group C was significant(P<0.05).Eradication rate of Group B and C was higher than that of Group D(P<0.05). There was no statistical difference between the eradication rate of Group B and C, and among the side effects of the 4 groups. Conclusion The strategy of RCF was the best among the 4 triple strategy of Hp eradication, which can be used clinically.
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